Endometrial angiogenic response in Norplant users

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Oxidative stress, vitamin E and progestin breakthrough bleeding.

Endometrial bleeding problems can be the major reason for discontinuing progestin-only contraception. In this study the endometrial angiogenic response in Norplant users was found to be lower than in women with normal menstrual cycles. These disturbances in angiogenic response may be caused by oxidant-antioxidant imbalance in the endometrium. The aims of this study were to investigate the effec...

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the study of alteration of endometrial basement membrane composition in norplant users

breakthrough bleeding (btb) is the cause of 50% of discontinuations of use by long-acting progestogen-only contraceptive users. btb appears to be associated with capillaries of abnormal morphology and fragility. disturbances in vessels integrity, intercellular junctions or alteration of the basement membrane (bm) composition has been proposed to contribute toward the fragility of these capillar...

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ژورنال

عنوان ژورنال: Human Reproduction

سال: 1996

ISSN: 0268-1161,1460-2350

DOI: 10.1093/humrep/11.suppl_2.51